The primary treatment for Candida diaper rash involves antifungal topical treatment and decreasing moisture in the diaper area. Nystatin (Mycostatin), clotrimazole (Lotrimin), and miconazole (Micatin, Monistat-Derm) are topical over-the-counter (non prescription) treatments of equal strength for treating Candida diaper dermatitis. Occasionally, other prescription antifungal creams, such as ketoconazole (Nizoral cream) and econazole (Spectazole) may be necessary. How long treatment should last has not been completely defined, although typically the cream or ointment is applied at each diaper change until the rash is resolved, usually in four to seven days.
Because of the intestinal reservoir of Candida species in most patients with yeast diaper rash, some doctors recommend oral antifungal medications in addition to topical creams. No study has definitively answered the question whether oral antifungal medications are helpful.
Some studies have indicated that preventing diaper rash may be done by applying barrier creams like zinc oxide (A & D Ointment, Desitin, Diaparene) or petroleum jelly (Vaseline, Aquaphor) to the diaper area after bathing. These products may help to decrease the ambient moisture in the diaper area after bathing or changing a diaper. Gentle cleaning to minimize skin breakdown may also be helpful. Air exposure (for example, no diaper) is also therapeutic.